Novels on Families
Pete Dexter lists his favorite novels about families.
It can be difficult to say that a novel is about a family when in most cases there is so much more packed into the story. Using a very loose standard, I'd add:
The Edge of Sadness by Edwin O'Connor
Tobacco Road by Erskine Caldwell
War and Peace by Leo Tolstoy
The Way We Live Now by Anthony Trollope