My hotel room has a unique alarm clock.
Instead of a buzzer or music, it makes noises resembling the sound of someone breaking into your room.
I must admit that it is rather effective.
My worst hotel experience, security-wise, took place somewhere in the Carolinas, where a client with usually impeccable taste booked me into a largely abandoned hotel similar to the one in "The Shining." I arrived around ten at night to find the huge lobby darkened but for a small light over the registration desk and a clerk who made Norman Bates seem normal. My room, once I found it, was down a long, barely lit, corridor and throughout my trek there was no evidence of any other guests. The bed, drapes, and chairs appeared not to have been used in a very long time. The bed sheets cracked from age. The highlight, of course, was when the door wouldn't completely close, much less lock. I piled chairs and luggage against it and went to sleep.
Business travel: Highly overrated.